2024 College Football Week 4 Picks vs Spread, Odds, Lines, Key Trends: Vegas Expert Reveals Picks

Legendary programs take center stage on the Week 4 college football schedule in two new conference games. In the Big Ten, new conference member No. 11 USC faces No. 18 Michigan on Saturday at 3:30 p.m. ET on CBS. The latest SportsLine Consensus college football odds for Week 4 have the Wolverines as 5-point underdogs after starting the year 0-3 against the spread. In the SEC, No. 6 Tennessee faces No. 15 Oklahoma as the Sooners play their first conference game in their new home as 6.5-point underdogs.

The Big 12 also has a top game pitting No. 12 Utah against No. 14 Oklahoma State (-2.5). This battle could be crucial in determining the conference champion. Before committing to college football picks for these or any other Week 4 games, be sure to check out legendary Vegas handicapper Bruce Marshall’s college football betting guide.

For years, Las Vegas-based Marshall was synonymous with The Gold Sheet, the famous sports betting newsletter. Having gained experience in live reporting and sports information while in college, Marshall joined TGS in 1981 when he was hired by the legendary Mort Olshan and served as managing editor for many years.

Bruce is a featured guest on numerous radio and television sports talk shows across the country. His extensive editorial work has been published in the Las Vegas Review-Journal, the New York Post and many other media outlets. He has won several handicapping titles and is also working on several book projects.

Using his Tech Corner technique that evaluates all the trends and the latest college football odds, Marshall has now turned his attention to college football betting for Week 4 and has released picks for each matchup. Click here to see all the picks.

Top College Football Predictions for Week 4

One of the top college football picks Marshall recommends for Week 4: He’s backing No. 14 Oklahoma (+6.5) to face No. 6 Tennessee at home on Saturday at 7:30 p.m. ET. This was one of the biggest line movers in Week 4, as Oklahoma was a favorite by as much as 5 points in the lookahead lines. It’s made it all the way to Tennessee -6.5, and Marshall has spotted some key trends tipping in Oklahoma’s favor.

After a slow start at OU, head coach Brent Venables has now led the way in seven of the last nine home games. Tennessee also struggled to get going on the road last year, only taking the lead once in five opportunities. The Vols have dominated so far, but this is by far their biggest challenge in terms of opposing talent and hostile environment.

The total has now dropped from 61.5 to 57.5, and Marshall is happy with the Over value, as these teams have combined to average 97.4 points per game so far in 2024. See what other picks you can make here.

How to make college football picks for week 4

Marshall has analyzed all the other matchups and discovered an alarming 11-0 betting trend you should know about this week. Get betting analysis for every matchup at SportsLine.

So what picks can you make with confidence on college football, and what alarming trend should you be aware of in one of the biggest games of the week? Check out the latest college football odds below, then head to SportsLine to see which teams you should be backing. All from the legendary Vegas expert who has won multiple handicapping titles and find out.

College Football Odds for Week 4

Here you will find all the tips, odds and predictions for college football in week 4

Friday, September 20

Stanford at Syracuse (-8.5, 56.5)

Illinois at Nebraska (-7.5, 42.5)

San Jose State at Washington State (-12, 55)

Saturday, September 21

North Carolina State at Clemson (-18.5, 44.5)

Florida at Mississippi State (+6, 58.5)

Marshall at Ohio State (-40, 52.5)

Arkansas at Auburn (-2.5, 56.5)

USC at Michigan (+5, 44)

Utah at Oklahoma State (-2.5, 52.5)

Tennessee at Oklahoma (+6.5, 57.5)

Louisiana-Monroe in Texas (-44.5, 52.5)

Baylor at Colorado (-1.5, 51.5)

Kansas State at BYU (+6.5, 48)